Trial literature on Ewing sarcoma

Last modification: 2017/01/05

Literature on Ewing sarcoma trials


  1. Grevener K, Haveman LM, Ranft A, van den Berg H, Jung S, Ladenstein R, Klco-Brosius S, Jürgens H, Merks JH, Dirksen U: Management and Outcome of Ewing Sarcoma of the Head and Neck. Pediatric blood & cancer 2016, 63: 604 [PMID: 26702872] GRE2016
  2. Foulon S, Brennan B, Gaspar N, Dirksen U, Jeys L, Cassoni A, Claude L, Seddon B, Marec-Berard P, Whelan J, Paulussen M, Streitbuerger A, Oberlin O, Jürgens H, Grimer R, Le Deley MC: Can postoperative radiotherapy be omitted in localised standard-risk Ewing sarcoma? An observational study of the Euro-E. W.I. N.G group. European journal of cancer 2016, 61: 128 [PMID: 27176931] FOU2016
  3. Bölling T, Braun-Munzinger G, Burdach S, Calaminus G, Craft A, Delattre O, Deley MC, Dirksen U, Dockhorn-Dworniczak B, Dunst J, Engel S, Faldum A, Fröhlich B, Gadner H, Göbel U, Gosheger G, Hardes J, Hawkins DS, Hjorth L, Hoffmann C, Kovar H, Kruseova J, Ladenstein R, Leuschner I, Lewis IJ, Oberlin O, Paulussen M, Potratz J, Ranft A, Rössig C, Rübe C, Sauer R, Schober O, Schuck A, Timmermann B, Tirode F, van den Berg H, van Valen F, Vieth V, Willich N, Winkelmann W, Whelan J, Womer RB: Development of curative therapies for Ewing sarcomas by interdisciplinary cooperative groups in Europe. Klinische Padiatrie 2015, 227: 108 [PMID: 25985445] BOE2015
  4. Bielack SS, Smeland S, Whelan JS, Marina N, Jovic G, Hook JM, Krailo MD, Gebhardt M, Pápai Z, Meyer J, Nadel H, Randall RL, Deffenbaugh C, Nagarajan R, Brennan B, Letson GD, Teot LA, Goorin A, Baumhoer D, Kager L, Werner M, Lau CC, Sundby Hall K, Gelderblom H, Meyers P, Gorlick R, Windhager R, Helmke K, Eriksson M, Hoogerbrugge PM, Schomberg P, Tunn PU, Kühne T, Jürgens H, van den Berg H, Böhling T, Picton S, Renard M, Reichardt P, Gerss J, Butterfass-Bahloul T, Morris C, Hogendoorn PC, Seddon B, Calaminus G, Michelagnoli M, Dhooge C, Sydes MR, Bernstein M, EURAMOS-1 investigators: Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial. Journal of clinical oncology 2015, 33: 2279 [PMID: 26033801] BIE2015
  5. Bedetti B, Wiebe K, Ranft A, Aebert H, Schmidt J, Jürgens H, Dirksen U: Local control in Ewing sarcoma of the chest wall: results of the EURO-EWING 99 trial. Annals of surgical oncology 2015, 22: 2853 [PMID: 26104542] BED2015
  6. van den Berg H, Paulussen M, Le Teuff G, Judson I, Gelderblom H, Dirksen U, Brennan B, Whelan J, Ladenstein RL, Marec-Berard P, Kruseova J, Hjorth L, Kühne T, Brichard B, Wheatley K, Craft A, Jürgens H, Gaspar N, Le Deley MC, Euro-EWING99 Group: Impact of gender on efficacy and acute toxicity of alkylating agent -based chemotherapy in Ewing sarcoma: secondary analysis of the Euro-Ewing99-R1 trial. European journal of cancer 2015, 51: 2453 [PMID: 26271204] BER2015
  7. Rasper M, Jabar S, Ranft A, Jürgens H, Amler S, Dirksen U: The value of high-dose chemotherapy in patients with first relapsed Ewing sarcoma. Pediatric blood & cancer 2014, 61: 1382 [PMID: 24729428] RAS2014
  8. Stahl M, Ranft A, Paulussen M, Bölling T, Vieth V, Bielack S, Görtitz I, Braun-Munzinger G, Hardes J, Jürgens H, Dirksen U: 19. Risk of recurrence and survival after relapse in patients with Ewing sarcoma. Pediatr Blood Cancer 2011,Epub ahead of print [PMID: 21442722 ] STA2011
  9. Thiel U, Wawer A, Wolf P, Badoglio M, Santucci A, Klingebiel T, Basu O, Borkhardt A, Laws HJ, Kodera Y, Yoshimi A, Peters C, Ladenstein R, Pession A, Prete A, Urban EC, Schwinger W, Bordigoni P, Salmon A, Diaz MA, Afanasyev B, Lisukov I, Morozova E, Toren A, Bielorai B, Korsakas J, Fagioli F, Caselli D, Ehninger G, Gruhn B, Dirksen U, Abdel-Rahman F, Aglietta M, Mastrodicasa E, Torrent M, Corradini P, Demeocq F, Dini G, Dreger P, Eyrich M, Gozdzik J, Guilhot F, Holler E, Koscielniak E, Messina C, Nachbaur D, Sabbatini R, Oldani E, Ottinger H, Ozsahin H, Schots R, Siena S, Stein J, Sufliarska S, Unal A, Ussowicz M, Schneider P, Woessmann W, Jürgens H, Bregni M, Burdach S, on behalf of the Solid Tumor Working Party (STWP) and the Pediatric Disease Working Party (PDWP) of the European Group for Blood and Marrow Transplantation (EBMT), the Asia Pacific Blood and Marrow Transplantation (APBMT), the Pediatric Registry for Stem: No improvement of survival with reduced- versus high-intensity conditioning for allogeneic stem cell transplants in Ewing tumor patients. Ann Oncol 2011, 22: 1614 [PMID: 21245159] THI2011
  10. Dirksen U, Jürgens H: Approaching Ewing sarcoma. Future Oncol 2010, 6: 1155 [PMID: 20624127] DIR2010
  11. Ladenstein R, Pötschger U, Le Deley MC, Whelan J, Paulussen M, Oberlin O, van den Berg H, Dirksen U, Hjorth L, Michon J, Lewis I, Craft A, Jürgens H: Primary Disseminated Multifocal Ewing Sarcoma: Results of the Euro-EWING 99 Trial. Journal of clinical oncology 2010, 28: 3284 [PMID: 20547982] LAD2010
  12. Burdach S, Thiel U, Schöniger M, Haase R, Wawer A, Nathrath M, Kabisch H, Urban C, Laws HJ, Dirksen U, Steinborn M, Dunst J, Jürgens H, Meta-EICESS Study Group: Total body MRI-governed involved compartment irradiation combined with high-dose chemotherapy and stem cell rescue improves long-term survival in Ewing tumor patients with multiple primary bone metastases. Bone marrow transplantation 2010, 45: 483 [PMID: 19684633] BUR2010
  13. Paulussen M, Bielack S, Jürgens H, Casali PG, ESMO Guidelines Working Group: Ewing's sarcoma of the bone: ESMO clinical recommendations for diagnosis, treatment and follow-up. Annals of oncology 2009, 20 Suppl 4: 140 [PMID: 19454436] PAU2009
  14. Bölling T, Dirksen U, Ranft A, Ernst I, Jürgens H, Willich N: Radiation toxicity following busulfan/melphalan high-dose chemotherapy in the EURO-EWING-99-trial: review of GPOH data. Strahlenther Onkol 2009, 185 Suppl 2: 21 [PMID: 19685030] BOE2009
  15. Boelling T, Schuck A, Pape H, Rube C, Pollinger B, Timmermann B, Kortmann RD, Dieckmann K, Willich N: Study protocol of the German . Radiation oncology 2008, 3: 10 [PMID: 18426567] BOE2008
  16. Bölling T, Schuck A, Paulussen M, Dirksen U, Ranft A, Könemann S, Dunst J, Willich N, Jürgens H: Whole lung irradiation in patients with exclusively pulmonary metastases of Ewing tumors. Toxicity analysis and treatment results of the EICESS-92 trial. Strahlentherapie und Onkologie 2008, 184: 193 [PMID: 18398583] BOE2008
  17. Pieper S, Ranft A, Braun-Munzinger G, Jürgens H, Paulussen M, Dirksen U: Ewing's tumors over the age of 40: a retrospective analysis of 47 patients treated according to the International Clinical Trials EICESS 92 and EURO-E. W.I. N.G. 99. Onkologie 2008, 31: 657 [PMID: 19060503] PIE2008
  18. Paulussen M, Craft AW, Lewis I, Hackshaw A, Douglas C, Dunst J, Schuck A, Winkelmann W, Köhler G, Poremba C, Zoubek A, Ladenstein R, van den Berg H, Hunold A, Cassoni A, Spooner D, Grimer R, Whelan J, McTiernan A, Jürgens H, European Intergroup Cooperative Ewing's Sarcoma Study-92: Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients. Journal of clinical oncology 2008, 26: 4385 [PMID: 18802150] PAU2008
  19. Ladenstein R, Whelan J, Oberlin O, Weston C, Juergens, H: A prospective multicentre evaluation of intensive treatment including high-dose chemotherapy and PSCR for Ewing's tumours with extra-pulmonary metastatic disease. Results from the Euro-Ewing 99 Study. Bone Marrow Transplant 2006, 37 Suppl.; 16 LAD2006b
  20. Lanvers-Kaminsky C, Bremer A, Dirksen U, Jürgens H, Boos J: Cytotoxicity of treosulfan and busulfan on pediatric tumor cell lines. Anti-cancer drugs 2006, 17: 657 [PMID: 16917211] LAN2006b
  21. Paulides M, Stohr W, Bielack S, Jürgens H, Koscielniak E, Klingebiel T, Zimmermann R, Stachel D, Langer T, Beck JD: Prospective evaluation of hepatitis B, C and HIV infections as possible sequelae of antineoplastic treatment in paediatric sarcoma patients: a report from the Late Effects Surveillance System. Oncology reports 2006, 15: 687 [PMID: 16465431] PAU2006a
  22. Bernstein M, Kovar H, Paulussen M, Randall, RL, Schuck A, Teot, LA, Juergens, H: Ewing Sarcoma Family of Tumors: Ewing Sarcoma of Bone and Soft Tissue and the Peripheral Primitive Neuroectodermal Tumors. Buch: Principles and Practice of Pediatric Oncology (Ed. Pizzo,P.A.; Poplack,D.G.) 2006, 5th Ed.;Ch.33; 1002 BER2006a
  23. Ladenstein R, Poetschger U, Hartman O, Jürgens H, Koscielniak E, Dallorso G, Doz F, Dini, G: Megatherapy/SCT activity in paediatric solid tumours in Europe. Bone Marrow Transplant 2006, 37 Suppl.; 149 LAD2006a
  24. Lanvers-Kaminsky C, Nolting DM, Koster J, Schroder A, Sandkotter J, Boos J: In-vitro toxicity of Ukrain against human Ewing tumor cell lines. Anti-cancer drugs 2006, 17: 1025 [PMID: 17001175] LAN2006a
  25. Franzius C, Juergens KU, Vormoor J: PET/CT with diagnostic CT in the evaluation of childhood sarcoma. AJR. American journal of roentgenology 2006, 186: 581; author reply 581 [PMID: 16423975] FRA2006a
  26. Whelan J, McTiernan A, Weston C, Douglas C, Grimer R, Cassoni A, Paulussen M, Jürgens H, Craft A, Lewis, I: Consequences of different approaches to local treatment of Ewing's sarcoma within an international randomised controlled trial: Analysis of EICESS-92. Journal of Clinical Oncology 2006, 24; 528S WHE2006
  27. Schuck A, Ranft A, Dirksen U, Dunst J, Jürgens H, Willich, N: Radiotherapy in Ewing tumours: Significance of fractionation. Strahlentherapie und Onkologie 2006, 182; 67 SCH2006
  28. Potratz J, Zoubek A, Bielack, S: Malignant bone tumors in children and adolescents. Monatsschr Kinderheilkd 2006, 154; 10 POT2006
  29. Borowski A, Dirksen U, Lixin L, Shi RL, Göbel U, Schneider EM: Structure and function of ETAA16: a novel cell surface antigen in Ewing's tumours. Cancer Immunol Immunother Vol.55; 2006, 363 [PMID: 16003559] BOR2006
  30. Kreuter M, Paulussen M, Boeckeler J, Gerss J, Buerger H, Liebscher C, Kessler T, Jürgens H, Berdel WE, Mesters RM: Clinical significance of Vascular Endothelial Growth Factor-A expression in Ewing's sarcoma. European journal of cancer (Oxford, England : 1990) 2006, 42: 1904 [PMID: 16824746] KRE2006
  31. Hunold A, Weddeling N, Paulussen M, Ranft A, Liebscher C, Jürgens H: Topotecan and cyclophosphamide in patients with refractory or relapsed Ewing tumors. Pediatric blood & cancer 2006, 47: 795 [PMID: 16411206] HUN2006
  32. Hoffmann C, Gosheger G, Gebert C, Jürgens H, Winkelmann, N: Functional results and quality of life after treatment of pelvic sarcomas involving the acetabulum. J Bone Joint Surg Am 88A; 3/2006, 575 HOF2006
  33. Gebert C, Brinkschmidt C, Bielack S, Bernhardt T, Jürgens H, Böcker W, Winkelmann W, Bürger H, Gosheger, G: The potential of comparative genomic hybridization as a tool in the differential diagnosis of matrix-producing bone lesions. Int J Surg Pathol 2006, 14: 187 [PMID: 16959697] GEB2006
  34. Franzius C, Hotfilder M, Poremba C, Hermann S, Schafers K, Gabbert HE, Jürgens H, Schober O, Schafers M, Vormoor J: Successful high-resolution animal positron emission tomography of human Ewing tumours and their metastases in a murine xenograft model. European journal of nuclear medicine and molecular imaging 2006, 33: 1432 [PMID: 16896672] FRA2006
  35. Bernstein M, Kovar H, Paulussen M, Randall RL, Schuck A, Teot LA, Jürgens H: Ewing's sarcoma family of tumors: current management. The oncologist 2006, 11: 503 [PMID: 16720851] BER2006
  36. Paulides M, Kremers A, Stohr W, Bielack S, Jürgens H, Treuner J, Beck JD, Langer T, German Late Effects Working Group in the Society of Pediatric Oncology and Haematology (GPOH): Prospective longitudinal evaluation of doxorubicin-induced cardiomyopathy in sarcoma patients: a report of the late effects surveillance system (LESS). Pediatric blood & cancer 2006, 46: 489 [PMID: 16333817] PAU2006
  37. Schuck A, Hamelmann V, Bramswig JH, Konemann S, Rube C, Hesselmann S, Riesenbeck D, Horst E, Bolling T, Paulussen M, Jürgens H, Willich N: Ovarian function following pelvic irradiation in prepubertal and pubertal girls and young adult women. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 2005, 181: 534 [PMID: 16044222] SCH2005k
  38. Schuck A, Ahrens S, von Schorlemer I, Kuhlen M, Paulussen M, Hunold A, Gosheger G, Winkelmann W, Dunst J, Willich N, Jürgens H: Radiotherapy in Ewing tumors of the vertebrae: treatment results and local relapse analysis of the CESS 81/86 and EICESS 92 trials. International journal of radiation oncology, biology, physics 2005, 63: 1562 [PMID: 16137838] SCH2005j
  39. Lanvers-Kaminsky C, Winter B, Koling S, Frodermann B, Braun Y, Schaefer KL, Diallo R, Koenemann S, Wai D, Willich N, Poremba C, Schuck A: Doxorubicin modulates telomerase activity in Ewing's sarcoma in vitro and in vivo. Oncology reports 2005, 14: 751 [PMID: 16077987] LAN2005d
  40. Paulussen M, Jürgens H, Dunst J, Schmoll, HJ, Winkelmann W, Hoffmann, C: Ewing-Tumor (Ewing-Sarkom und maligner peripherer neuroektodermaler Tumor, PNET). Book Chapter In "Kompendium Internistische Onkologie, Standards in Diagnostik und Therapie - Teil 2: Therapiekonzepte maligner Tumoren" (Ed. Schmoll,H.J.; Höffken,K.; Possinger,K.) 2005, 4th Ed.; 5292 PAU2005b
  41. Paulussen M, Kovar H, Jürgens H: Ewing sarcoma and peripheral PNET. Buchbeitrag 2005, 5. Aufl. PAU2005a
  42. Daecke W, Ahrens S, Jürgens H, Martini AK, Ewerbeck V, Kotz R, Winkelmann W, Bernd L: Ewing's sarcoma and primitive neuroectodermal tumor of hand and forearm. Experience of the Cooperative Ewing's Sarcoma Study Group. Journal of cancer research and clinical oncology 2005, 131: 219 [PMID: 15614525] DAE2005a
  43. Paulides M, Stöhr W, Bielack S, Jürgens H, Treuner J, Schuck A, Willich N, Sauer R, Dörr, HG, Rascher W, Langer T, Beck, JD: Major sequelae of antineoplastic therapy prospectively evaluated in 162 relapse-free adult sarcoma patients. Onkologie 2005, 28;S3; 56 PAU2005
  44. Masjosthusmann K, Bielack SS, Kohler G, Florax A, Schiborr M, Bruch J, Reinhardt D, Kuhn N, Paulussen M, Jürgens H: Concomitant Ewing sarcoma and acute lymphoblastic leukemia in a 5-year-old girl. Pediatric blood & cancer 2005, 45: 846 [PMID: 15926159] MAS2005
  45. Machatschek JN, Paulussen M, Bielack S: Chemotherapie bei malignen Knochentumoren. Buchbeitrag 2005 MAC2005
  46. Konemann S, Bolling T, Kolkmeyer A, Riesenbeck D, Hesselmann S, Vormoor J, Willich N, Schuck A: Heterogeneity of radiation induced apoptosis in Ewing Tumor cell lines characterized on a single cell level. Apoptosis 2005, 10: 177 [PMID: 15711933] KON2005
  47. Hotfilder M, Sondermann P, Senss A, van Valen F, Jürgens H, Vormoor J: PI3K/AKT is involved in mediating survival signals that rescue Ewing tumour cells from fibroblast growth factor 2-induced cell death. British journal of cancer 2005, 92: 705 [PMID: 15685229] HOT2005
  48. Gerth HU, Rompel A, Krebs B, Boos J, Lanvers-Kaminsky C: Cytotoxic effects of novel polyoxotungstates and a platinum compound on human cancer cell lines. Anti-cancer drugs 2005, 16: 101 [PMID: 15613912] GER2005
  49. Schuck A, Kuhlen M, von Schorlemer L, Ahrens S, Hunold A, Konemann S, Dunst J, Winkelmann W, Jürgens H, Willich N : Radiotherapy in Ewing's tumors of the vertebral column - Results and analysis of local recurrences. STRAHLENTHERAPIE UND ONKOLOGIE 180: 24-24 Suppl. 1, JUN 2004 [ISSN: 0179-7158] SCH2004g
  50. Paulussen M, Jürgens H: Ewing-Sarkom und PNET. Buchbeitrag 2004 PAU2004