UMBRELLA

Kidney tumors

Prospective, international, non-randomized trial

Overall aim

The overall aim of the SIOP 2016 UMBRELLA protocol is to harmonize the clinical relevant standard diagnostic procedures for all paediatric renal tumours within SIOP and to provide imaging studies and biomaterial from all of these patients, to find new and better risk factors for treatment stratification and molecular targets for novel therapeutic approaches. This will help to improve short and long term outcomes for all children with renal tumours through the introduction of a more ‘personalised’ approach.

Primary objectives

• To show the feasibility of storing serial blood, urine samples, tumour and germline material at diagnosis and at specific time points during treatment for international collaborative studies.
• 1q gain and genomic copy number biomarkers: To assess genomic 1q gain as a prognostic biomarker in WT.
• Volume of blastema: To optimise the definition of high risk WT, ‘blastemal type’.
• Radiology review: To optimise radiological diagnostics by (real time) central review.
• Pathology review: To optimise pathological diagnostics by (real time) central review.

Die SIOP 2016 enthält Behandlungsempfehlungen zur Therapie von Wilmstumoren der Niere, weiteren Nierentumoren sowie metastasierten und rezidivierten Nierentumoren.
Die Behandlungsempfehlungen basieren auf den Ergebnissen der Vorgängerstudie SIOP 2001. In der SIOP 2016 werden keine neuen Studienfragen gestellt.

All children, adolescents or young adults with a primary or relapsed renal tumour diagnosed in a participating SIOP-RTSG centre are eligible for inclusion in the SIOP 2016 UMBRELLA study.

The only exclusion criterion is missing informed consent.