CWS-Guidance

The CWS-Study-Grpup provides all participating centres of the registry SoTiSar with a threrapy guideline. The" CWS-Guidance" is a guideline for the teatment of patients with a soft-tissue-tumour or sarcoma with the following tumourgroups or clinical situations:

Lokalisierte Rhabdomyosarkome: Im Rahmen der European Soft Tissue Sarcoma Study Group (EpSSG), einem Verbund der drei europäischen Weichteilsarkom-Studiengruppen (CWS, SIOP-MMT und AIEOP STSC, ehemals ICG) wurde im Jahr 2004 Localized rhabdomyosarcoma: Based on the results of the European Soft Tissue Study Group (EpSSG) a new risk grouping system and a standard-therapy for patients with local RMS has been developed in the year 2004 as a Pan European consenus. This therapy, which is actually the best known, is part oft the CWS-Guideline.
In addition the CWS-Guidline provides therapy-guidelines for:

Other local "RMS-like" tumours:Extraosseous Ewing tumours, Peripheral primitive neuroectodermal tumour, Synovial sarcoma, Undifferentiated sarcoma

Non-rhabdomyosarcoma ("NRSTS")

Metastatic patients

“Second line” Chemotherapy: Possible fpr patients with only partial-response, stable desease or relapsed desease

Fibromatosis and Myxofibromatosis

Pleuropulmonary Blastoma: (in cooperation with the International Pleuropulmonary Blastoma Registry, USA, CWS-Coordinator Dr. Sylvia Kirsch)

Gastrointestinal Stroma Tumour and Dermatofibrosarcoma protuberans: (in cooperation with the European Working Group on Pediatric GISTs, CWS-coordinator PD Dr. Martin Benesch, Graz, Österreich)

The CWS-Guidance contains todays best known, standardised therapy-guideline for different soft-tissue tumours and sarcoma. It is based on the results of the european trials CWS-81, 86, 91, 96 and 2002P and other international trials. For patients with RMS a therapy is recommanded, which was developed in 2004 with experts of the "European paediatric Soft Tissue Study Group" as a european standard.

The therapy-arms will be stratified accordingly to the tumourtype (Rhabdomyosacoma, RMS-like tumours, Non-RMS-like tumours, other soft-tissue-tumours) and the risk-factors (histology, post surgical stage, tumour site, node involvement, initial tumour size and patients’ age).
Patients with a local High-risk Rhabdomyosarcoma, who reached a complete remission after a multimodal chmeotherapy can take part in the randomized, proospective, multinational trial CWS-HR 2007 with the objective to improve the therapy.

Target population for the teatment:

• Pathologisch –anatomisch bewiesene Diagnose (zentrales Review-Verfahren) eines Weichteiltumors bei Patienten ≤ 21 Jahre (d.h.20 Jahre und 364 Tage)
• Patienten mit Rhabdomyosarkomen können auch eingeschlossen werden, wenn sie älter als 21 Jahre sind.

Coordination

Dr. med. Tobias Dantonello, Dr. med. Monika Sparber-Sauer, Dr. med. Monika Scheer
Klinikum Stuttgart - Olgahospital
Klinik für Kinder- und Jugendmedizin - Pädiatrie 5,
Studienzentrale CWS
Kriegsbergstrasse 62
70174 Stuttgart
Telefon +49 (711) 278 73870
Fax +49 (711) 278 72749
cws@olgahospital-stuttgart.de